Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting in pregnancy. It is generally described as unrelenting, excessive pregnancy-related nausea and/or vomiting that prevents adequate intake of food and fluids. If severe and/or inadequately treated, it is typically associated with:
-loss of greater than 5% of pre-pregnancy body weight (usually over 10%)
-dehydration and production of ketones
-nutritional deficiencies
-metabolic imbalances
-difficulty with daily activities
Most affected women have numerous episodes of vomiting throughout the day with few if any symptom-free periods, especially during the first three to four months. This leads to significant and rapid weight loss, dehydration, electrolyte disturbances, and nutritional deficiencies often requiring hospitalization.
Symptoms such as changes in taste or smell, nausea and vomiting usually begin around week 4-6 and peak between 9-13 weeks. Onset of symptoms may occur before the pregnancy is confirmed by an elevation in hCG level (positive pregnancy test). Typically, there is resolution or at least significant improvement somewhere around 14-20 weeks, however, some women (10-20% or more) continue to require significant care for their entire pregnancy.
Most affected women have numerous episodes of vomiting throughout the day with few if any symptom-free periods, especially during the first three to four months. This leads to significant and rapid weight loss, dehydration, electrolyte disturbances, and nutritional deficiencies often requiring hospitalization.